امروز جمعه , 02 شهریور 1403
شنبه تا پنج شنبه - 9 صبح الی 20 عصر
دانلود مقاله : Inversion of lefteright asymmetry alters performance of Xenopus tadpoles in nonlateralized cognitive tasks 2013
![دانلود مقاله : Inversion of lefteright asymmetry alters performance of Xenopus tadpoles in nonlater](/content/productpic/100765309c28b-d109-436e-a7cd-8b34609d1c1d.png)
دانلود مقاله :
Inversion of lefteright asymmetry alters performance of Xenopus tadpoles in nonlateralized cognitive tasks 2013
نویسندگان :
Douglas J. Blackiston, Michael Levin
فرمت:pdf
چکیده :
Lefteright behavioural biases are well documented across the animal kingdom, and handedness has long
been associated with cognitive performance. However, the relationship between body laterality and
cognitive ability is poorly understood. The embryonic pathways dictating normal lefteright patterning have
been molecularly dissected in model vertebrates, and numerous genetic and pharmacological treatments
nowfacilitate experimental randomization or reversal of the lefteright axis in these animals. Several recent
studies showed a link between brain asymmetry and strongly lateralized behaviours such as eye use preference.
However, links between laterality of the body and performance on cognitive tasks utilizing nonlateralized
cues remain unknown. Xenopus tadpoles are an establishedmodel for the study of early lefteright
patterning, and protocols were recently developed to quantitatively evaluate learning and memory in these
animals. Using an automated testing and training platform,we tested wild-type, lefteright-randomized and
lefteright-reversed tadpoles for their ability to learn colour cues in an automated assay. Our results indicate
that animals with either randomization or reversal of somatic lefteright patterning learned more slowly
than wild-type siblings, although all groups were able to reach the same performance optimum given
enough training sessions. These results are the first analysis of the link between body laterality and learning
of nonlateralized cues, and they position the Xenopus tadpole as an attractive and tractable model for future
studies of the links between asymmetry of the body, lateralization of the brain and behaviour.
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